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Depart from Nea Anchialos and head east.  Turn left onto 30 and take ramp right for E75. Keep straight onto E75.  Take ramp right toward Lamia / Karpenisi / Domokos / Trikala.  Keep straight onto Ethniki Odos Lamias Trikalon and turn left onto E952 / Gennimata.  Keep straight onto Kalantzi E. and continue onto Karpenisiou - Lamias. (Follow signs to Makrakomi). When you enter Makrakomi you will turn right (signs to Platystomo) and then turn left (signs to Loutra Platystomou). When you enter Loutra Platystomou you will find THERMAE PLATYSTOMOU RESORT & SPA